Nenagh College offers a wide variety of school clubs and Activites including:
- Hurling
- Football
- Jit Jitsu
- Basketball
- Orienteering
- Soccer
- Volleyball
- Swimming
- Amber Flag
- Camogie
- Rugby
- Nature Hiking
- Gaisce
- Computers
- Robotics
- Drama
- Film workshops
- Students Council
- Homework Club
- Big Brother Big Sister
- Trad Group
- Creative Engagement
- Junior Achievement
- Student Enterprise
- Foreign Trips
- Excursions
- Guest Speakers
- Adventure Centre Visits
- St. Vincent De Paul
- Charity Fundraisers
